MP260INTERLEUKIN(IL)-36 AXIS IS MODULATED IN MICE AKI MODEL AND HUMAN URINE AND HUMAN AKI URINE AXIS IS MODULATED IN MICE AKI MODEL AND HUMAN AKI URINE
نویسندگان
چکیده
منابع مشابه
Therapeutic Targets of Human AKI: Harmonizing Human and Animal AKI.
The opportunity to make advances in the prevention and treatment of AKI has never been greater than it is today. Major advances have been made in the understanding of the biology of AKI, the design of clinical trials, and the use of diagnostic and prognostic biomarkers. These advances have been supplemented by the coordinated effort of societies, federal agencies, and industry, such that we are...
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The concept of acute kidney syndromes has shifted in recent years from acute renal failure to acute kidney injury (AKI). AKI implies injury or damage but not necessarily dysfunction. The human kidney has an important glomerular function reserve, and dysfunction becomes evident only when more than 50% of the renal mass is compromised. Recent AKI classifications include even slight changes in ser...
متن کاملClassifying AKI by Urine Output versus Serum Creatinine Level.
Severity of AKI is determined by the magnitude of increase in serum creatinine level or decrease in urine output. However, patients manifesting both oliguria and azotemia and those in which these impairments are persistent are more likely to have worse disease. Thus, we investigated the relationship of AKI severity and duration across creatinine and urine output domains with the risk for RRT an...
متن کاملHow can urine microscopy influence the differential diagnosis of AKI?
A cute kidney injury (AKI), which is associated with increased morbidity and mortality, is a relatively common complication in hospitalized patients (1–3). The most common cause of AKI in hospitalized patients is acute tubular necrosis (ATN) followed by prerenal azotemia (4). Because therapies and prognoses for prerenal azotemia and ATN differ substantially, early clinical differentiation is de...
متن کاملHuman AKI and heme oxygenase-1.
Findings derived from animal models of AKI gain clinical credence and appeal when translational studies corroborate their occurrence in human AKI. In the current issue of JASN, Zager et al. take important steps in addressing the clinical applicability of the conclusion drawn from animal models that induction of heme oxygenase-1 (HO-1) is a protective response in AKI. The major heme-degrading me...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2017
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfx166.mp260